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Before beginning the Introduction to Pharmacology Course, please take it and go to the class with an open mind, ready to learn. the nurse checks a medication profile to look for possible drug interactions and notes that warfarin and aspirin are prescribed. What is the rationale for the initial dose? in order to move through the body, drugs must be able to cross membranes to: - enter the blood stream from the site of administration, the movement of a drug from its site of administration into the blood, Pattern of absorption of a subQ injection, Barriers to absorption: capillary wall (same as IM), Barriers to absorption: lining of GI tract, capillary walls, distribution is the movement of drugs throughout the body, the enzymatic alteration of drug structure, therapeutic consequences of drug metabolism, excretion is the removal of drugs from the body. a nurse administers the same medication in the same preparation in the same dose to several patients and notes that some patients have a better response than others. 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